FGF2 fibroblast growth factor 2 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: FGF2provided by VGNC
Official Full Name: fibroblast growth factor 2provided by VGNC
Primary source: VGNC:VGNC:107260
See related: BGD:BT10549
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: BFGF; FGF-2; HBGF-2
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	17	NC_037344.1 (34801330..34860849, complement)

Chromosome 17 - NC_037344.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037344.1 Chromosome 17 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cell Density-Dependent Fibroblast Growth Factor-2 Signaling Regulates Syndecan-4 Expression in Cultured Vascular Endothelial Cells.
Title: Cell Density-Dependent Fibroblast Growth Factor-2 Signaling Regulates Syndecan-4 Expression in Cultured Vascular Endothelial Cells.
Initiation of Conceptus Elongation Coincides with an Endometrium Basic Fibroblast Growth Factor (FGF2) Protein Increase in Heifers.
Title: Initiation of Conceptus Elongation Coincides with an Endometrium Basic Fibroblast Growth Factor (FGF2) Protein Increase in Heifers.
These data support the contention that FGF2 and TGFB1 modulate THBS1 via miR-221.
Title: Fibroblast growth factor-2 and transforming growth factor-beta1 oppositely regulate miR-221 that targets thrombospondin-1 in bovine luteal endothelial cells.
activation of FGFR1 and FGFR2 by uterine- and endometrial-derived FGF2 stimulates PI3K/AKT and mitogen-activated protein kinase pathways for development of the porcine uterus and improvement of litter size
Title: Stimulatory effects of fibroblast growth factor 2 on proliferation and migration of uterine luminal epithelial cells during early pregnancy.
Taken together, Staphylococcus aureus induces TGF-beta1 and bFGF expression through the activation of AP-1 and NF-kappaB in bovine mammary gland fibroblasts.
Title: Staphylococcus aureus induces TGF-β1 and bFGF expression through the activation of AP-1 and NF-κB transcription factors in bovine mammary gland fibroblasts.
Data suggest THBS1 (thrombospondin-1) expression predominates in luteal endothelial cells; THBS2 expression predominates in luteinized granulosa cells. Luteinizing signals down-regulate expression of THBS1/THBS2 but up-regulate expression of FGF2.
Title: Functions and transcriptional regulation of thrombospondins and their interrelationship with fibroblast growth factor-2 in bovine luteal cells.
Mixed populations of luteal cells were treated with SU1498 (VEGF receptor 2 inhibitor) or SU5402 (FGF receptor 1 inhibitor) or control on days 0-3, 3-6 or 6-9 to determine the role of FGF2 and VEGFA during these specific windows.
Title: Fibroblast growth factor 2 is a key determinant of vascular sprouting during bovine luteal angiogenesis.
FGF2 was crucial for luteal endothelial network formation.
Title: FGF2 is crucial for the development of bovine luteal endothelial networks in vitro.
Associations between reproduction and milk traits, and polymorphisms at the STAT5A and FGF2 gene loci, were found with STAT5A polymorphism for age at first calving (suggestive effect; P =0.077) and lactation milk yield (significant effect; P<0.05).
Title: Effect of polymorphisms at the STAT5A and FGF2 gene loci on reproduction, milk yield and lameness of Holstein cows.
FGF2 and FGF10 regulate migratory activity of ovine trophoblast cells through MAPK-dependent pathways.
Title: Fibroblast growth factors activate mitogen-activated protein kinase pathways to promote migration in ovine trophoblast cells.

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General gene information

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Markers

Fgf2 (e-PCR), detects polymorphism
- UniSTS:464707

FGF2 (e-PCR), detects polymorphism
- UniSTS:278381

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables fibroblast growth factor receptor binding	IEA Inferred from Electronic Annotation more info	PubMed
enables growth factor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of protein phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of cell migration	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: fibroblast growth factor 2

Names: basic fibroblast growth factor; fibroblast growth factor 2 (basic); heparin-binding growth factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174056.4 → NP_776481.2 fibroblast growth factor 2 precursor

Status: VALIDATED

Source sequence(s)

DAAA02044761

UniProtKB/TrEMBL

F1N3T9

Conserved Domains (1) summary

pfam00167
Location:28 → 149

FGF; Fibroblast growth factor